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1. Forklare forskelle mellem RNA og DNA
Stryer, s.26-28
Devlin, s.78
There are 3 important differences between DNA and RNA:
RNA’s sugar
component is ribose that has a 2`-OH group, while DNA has deoxyribose that has
only –H atom in position 2`. The 2`-OH group makes RNA unstable because it
becomes more susceptible to a base-catalysed hydrolysis. The removal of the
2`-OH group from ribose and replacement with 2`-H atom decreases the rate
of hydrolysis by approximately 100-fold under neutral conditions and
perhaps even more under extreme conditions.
RNA contains uracil, while DNA contains thymine, which is a methylated uracil. The methylation facilitates the repair of damaged DNA.
(these two differences make DNA more suitable as genetic material)
RNA molecules are
usually one-stranded molecules, while DNA is double stranded. Thus, molar
ratios (A+U) and (G+C) are not equal. In some viruses double stranded RNA can
also be found.
RNA has
enzymatic activity and DNA doesn't
DNA has permanent mutations, while if a mutation fx. happens in an mRNA molecule, only that mRNA and the protein that is translated from it are affected.
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